Categories
Science News

Let’s get to know about ‘ Calcitonin

Calcitonin (also known as thyrocalcitonin) is a 32-amino acid linear polypeptide hormone. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. There are 2 numbers of copies of the gene in the human genome on chromosome 11. It may be used diagnostically as a tumor marker for medullary thyroid cancer, in which high calcitonin levels may be present and elevated levels after surgery may indicate recurrence. Increased levels of calcitonin have also been reported for various other conditions. They include: C-cell hyperplasia, Nonthyroidal oat cell carcinoma, Nonthyroidal small cell carcinoma and other nonthyroidal malignancies, acute and chronic renal failure, hypercalcemia, hypergastrinemia and other gastrointestinal disorders, and pulmonary disease.

Categories
Science News

What is antibody dependent enhancement (ADE)

2. Serum or plasma transfers from patients who have survived an infection (convalescent plasma or serum) were a promising therapy prior to development of specific drugs. Currently, these transfers are still used, particularly for emerging infections or deadly infections without a therapy. When serum transfers are effective treatments, monoclonal antibodies may also provide protection. One possible hindrance to these therapies is the potential for antibody dependent enhancement (ADE) of infection.

a. (5 pts) There are two main mechanisms for ADE. Based on your knowledge of antibody functions, what are these two mechanisms?

The antibody dependant enhancement (ADE) is a phenomenon that is responsible for giving rise to severe immunopathogenesis of an infection upon a secondary infection. The ADE aids in the onset of a adverse effects of an otherwise neutral or less severe infection, in creation of a series of events that will conclude production of an serious and severe infection. The ADE is observed usually happens in diseases like dengue or AIDS. In context with the dengue fever once a person a gets infected with the dengue virus the viral load and the diseases pathogenesis decide the severity of the infection leading to Dengue haemorrhagic fever or Dengue shock syndrome. The ADE also plays a major role in this process in the capacity of immunopathogenesis via alteration of certain innate and adaptive immunity pathways. Dengue virus has 4 serotypes and when a person gets infected with one serotype of dengue virus, during and post infection the adaptive immune system produces antibodies against that particular serotype but also produces heterotypic antibodies against other serotypes. The immune protection against the infected serotype will be long lasting while the heterotypic antibodies provide protection only for a limited time (1 -2 years). When this individual gets infected with a different type of a dengue viral serotype the heterotypic antibodies cannot elicit an immune response but hence aids in the disease development and enhances its effects thus increasing the severity. The ADE performs this function in multiple ways but there are two main mechanisms to be followed and those are the intrinsic mechanism and extrinsic mechanism.

In the extrinsic mechanism the heterotypic antibody binding to the virus of another serotype helps the virus to gain entry inside the Dendritic cells (DC) in the skin. The antibody attachment to the virus is suppose to neutralize the viral action but in this scenario instead of eliciting immune action of prohibiting the virus action this binding helps the virus to gain entry inside the body. The binding mainly occur through the Fc receptor and the virus can camouflage itself inside the cell with the help of this process. T

he binding is meant to neutralize the virus surface protein from attaching to the cell, but the

antibody bound to virus also binds to the receptor of the cell, the Fc-region antibody receptor FcγR. This

action brings the virus into close proximity to the virus-specific receptor, and the cell internalizes the

virus through the normal infection route. Once inside the cell they can replicate and produce multiple

viral particles thereby increasing the viral load thus increasing the severity of the infection.

In the intrinsic mechanism the attachment of a different serotype to the virus surface protein can

demodulate and modify the innate immune responses by gaining entry to the DC cells through antibody

mediated route as described above. The alteration occurs along both TLR (toll like receptor) dependant

and independent pathways. The virus can target the TLR dependant pathway by up regulating the

b. (5 pts) How would a researcher determine whether an antibody causes ADE in vitro? Briefly , describe the assay/experiment.

The in vitro determination of whether an antibody can cause ADE can be described as follows. A human cell line such as THP-1 can be used and they can be cultured by using a culture media which contains a serum such a fetal bovine, glutamine and other nutrients and vitamins with correct pH in a CO2 incubator with rotating flask under correct CO2 and O2 percentages. After successful culturing we can perform cell passaging to obtain a functioning monolayer culture of THP-1 cells to perform our experiment. The cell line firstly in being infected by dengue virus (DENV) of serotype 1 (DENV-1) and it is allowed for some time for the infection to spread and register itself in the cell line. After the allocated time a microscopic slide preparation will be performed and will be observed under microscope to detect infection and to confirm infection ELISA assay for DENV-1 will be performed and this will confirm the presence of the DENV-1 antigen. The viral titre calculation will be done via using the flow cytometry by using FACS (fluorescent activated cell sorting) using negative controls with no virus. After allowing sometime for the cell line to alter and modulate itself to the infection, a secondary infection will be given to the cell line of DENV-2 serotype. Same amount of time as previously will be allocated for the infection to successfully register in the cells. The confirmation of the infection will be done by preparing a microscopic slide and observing under the microscope and also by using the ELISA assay for DENV-2 to confirm infection. The viral titer calculation will be done as same as previously by using FACS procedure using negative controls. The viral titer count for DENV-1 will be compared with the viral titer count for the DENV-2 infection and if the ADE phenomenon or antibody causes ADE in vitro the viral titer count will be higher for DENV-2, secondary infection than DENV-1, primary infection. The primary infection and secondary infection both will be performed under same conditions and the conditions for the cell line will be maintained same throughout the experiment.

negative TLR expression regulators and ADE has the ability to shift the TLR signaling into non NF-κB to

signalling along a non-NF-κB pathway. This helps in facilitating the increased replication and viral protein

production inside the cell. ADE can also modify the IFN pathways and they work by reduction of IFN

activity especially IFNβ expression.

Categories
Sport News

What? Why? Messi?

At 7:00 PM on Tuesday 25 August, Alfredo Martinez, a Honda Zero radio reporter, was the first to tweet, “Leo Messi sent burofax to the Bar. Selona wants to move the team. He wants to use the option to cancel the contract automatically immediately. “
And then is erysipelas Because the matter is true Messi wants to move away from Barcelona. The club where he lived for 20 years.
The beginning of the Messi incident This happened since Barcelona lost 8-2 Bayern painfully eliminated the Champions League. Summary This year the club does not have a single championship. That led the team management to dismiss Quique Setian from his position. Then appointed Ronald Khuman replaces
Barcelona gave the man the right to manage. To keep who to use And who will throw away who left, which koo it wants to release the older players With expensive wages away from the team
But the person he was determined to keep was Lionel Messi, so Khuman spoke to Messi on Friday. But after discussion Messi still hesitated. He still has to decide whether to stay well or not.
While everyone had to hope that Messi would stay or go There was a new bomb blast on Sunday. When there was news that one of the players that Ku Man was going to throw away was Luis Suarez.
Since Suarez moved to Barca in 2014, he has been the club’s immediate key man. Suarez shot spread. Until the record is the club’s third highest scoring player of all time
In addition to the field matters, Suarez is also very close to Messi. That’s because they were both born the same year. (Suarez older than 5 months) is the same South American. And the family of Messi and Suarez are close together, these two houses are always a couple pack.
When Kuman decided not to use Suarez and was ready to cancel his contract That point is understandable It is the coach’s approach. But the point that makes it dramatic is The person who called to say The club will cancel the contract and not return the team management. But instead of a moan Someone who has just moved for a few days I have to bear the face of calling Suarez myself.
Kuman talks to Suarez for just one minute and then sends the matter to the lawyers of both sides to continue discussing the severance of the contract.
Suarez was not satisfied with this kind of separation. Because he is dedicated to Barcelona for a full 6 years, helping the team to win many championships. So it is expected that If it will end together Should receive more club honors

Bad treatment with Suarez Combined with many feelings that have been accumulated for a long time It became an important trigger for Messi to tell the club that he was not enough.

[Why did Messi choose to go]
In that corner of Messi We know that He has long been unhappy with the management of the board.
Many decisions Of the executives doing anything wrong Causing Barca from the world’s number 1 team to become a champion team. And has not become a formidable team again
Argentinian media pointed out that the four main reasons Messi was thinking about moving the team were:
1) All failed trades Shows skill in management
Back in 2017, Neymar’s loss to PSG. Okay, it happened. But Messi, at least, sees the management more serious in bringing Neymar back to Camp Nou.
“I know negotiating with Paris Saint-Germain is not easy. But I don’t know if Barcelona have done everything to get Neymar back, ”Messi once said. Which during the last summer When Neymar had a serious problem with PSG, honestly, if Barca was a little serious. Had the right to get Neymar back
However, Board Barca did not take Neymar. But went to choose Antoine Griezmann from Atletico Madrid instead, which is not Griezmann, is not good. But since you know Neymar will definitely play with the Barca system. And why didn’t you work hard to get Neymar? Here, Griezmann has not yet known how well he will play. Plus the age of Greecemann is more than Neymar. Has a less period of use
And many more deals Where Barca made a mistake Pay more than they should be The one that should be bought is not bought. So Messi doesn’t understand if the club is still serious about winning or not. And the rest of his career is becoming less and less. Will he leave a champion like this until the day of hanging out?
2) doing something over the head
Dismissing Ernesto Valverde and appointed Quique Setian replaces It is a surprise Is that Balberde may not like the fans or whatever But the coach’s degree is still much better than Setian.
“Today it’s sad for our club. The great coach had to leave the team, ”Messi said of Valverde on the day he learned of the news that Balberde was fired.
When choosing to appoint Setian Club president Josep Maria Bartomeu calls out three players, Gerard Pique, Sergio Busquette and Sergie Roberto. Without consulting Messi as well So he himself felt that This change I myself have no part. In spite of being a true captain
3) Tired of having conflicts with management.
During the year there was a lot of drama for Messi. Chasing since the issue that sporting director Eric Abidal once interviewed that a Barca player intentionally saw Balberde’s leg. Until Messi had to come out and ask Abidal if “Tell me who you name” to protect the team Including the management board Used to pressure Barca players to reduce wages during COVID Which Messi had to protect the team again By saying that the players are willing to do so Not seen required This kind of coercive press from the press.
Messi has always been protecting the players on the team. Armed with the management until he was tired Is that playing ball only is already heavy Still have to come and manage the curtain outside the field

many other options
Messi at the age of 33 is still world class for many years. Messi’s brand is still going strong. The footsteps are still great. Therefore, it is not strange that other clubs However, I want it.
Which the other team both gave more money More honorable And of course, there is no need for drama to make him uncomfortable. Late career With still having time to win a major championship, it would be nice if he had full focus on football. And avoid the dramas found in everyday life

The reason is so clear That the move would have been a good cut, really if Barca wanted to keep Messi. Should be more careful But when there was an issue with Luis Suarez, another flower became the last straw. That made Messi decide to send a fax to the club to ask to move the team.

[Why should Barca release it? )
The issues most people in the world are talking about are Should Messi stay or should move, no one will give the answer as good as himself.
But another equally interesting issue is in the corner of Barcelona? They want to keep Messi. Or would you rather let go?
Of course, the opinion most fans would like to have Messi anyway, but not 100% of them think so. Some people think If the club really wants to move on, cutting Messi might be the right thing.
Oscar Rookery of Argentina’s 1986 World Championships has analyzed the situation that Barca really wanted to get rid of Messi as well. But cannot do it directly Because of the influence of the players There are so many Therefore, it must use a counterculture method. That is, let Suarez leave. In order to force Messi to announce himself That he wanted to move by himself Barca wasn’t planning on selling it.
“This eye piece Barcelona have planned. Cutting off Suarez It’s indirect pressure They intend to release Messi, of course, ”Rookery analyzed.
Why did Barca have to lose Messi? The first reason is Messi’s wages are very high, € 750,000 a week, and combined with the image royalties that Barca has to pay Messi every year, in total, Messi earned almost € 1 million.
Which if Barca is thinking of creating a new team It is necessary to find at least 4-5 quality players into the team. But when the wage ceiling is full of max like this To expand it is difficult. So if Messi goes Able to clear the wage ceiling a lot
For example, Inter Milan’s Lautaro Martinez is reportedly paying a meager € 96,000 a week. It is almost 8 times less than Messi. So if Messi just one person The team structure is much lighter.
Another reason to support Messi’s release. That is, Messi’s influence is too great. Both on and off the field
Spanish media revealed Cuoman’s conversation with Messi on Friday. There is an important highlight, Khoo Man said Messi is an important person in the team, but “your privileges in the team. No more You have to do everything for the team. And I can say that There will be no flexibility whatsoever, players have to think about the team first.
Words of Cuuman Media on two issues The first is the tactics in the field. That’s because Barca in the latter. There will always be Messi at the center. You have to think about Messi first. Which Khuman plan There will be no player at the center. But everyone will be equally important. To make the team win
The other point is Messi has so much power that The coach was hard to touch. In the previous seasons there were cases where Messi Not listening to Edair Sarabia’s game, Quique Setien’s right-hand man was walking out of the circle at a team meeting. Which at this point Kuoman did not want it to happen in his generation Even if it’s a star Must listen to what the coach is trying to say
While a portion of the fan’s corner indicates that Messi has a lack of energy in the latter part. He is the real captain. But rarely motivate teammates Team time behind Messi is often depressed. Which resulted in poor team timing as well
So the separation right here It might be a good thing, different people move on to start their own path again.

[Why should Barca keep? )
But, of course, comments from most of Barca’s fans. I don’t want to lose Messi.
The first step is about footsteps. Even though Messi is now 33 years old, he goes to see his work in the field He is a La Liga scorer with 25 goals and is the league’s top assist, making 21 assists despite the team not winning any title. But his personal work is still as great as before.
Messi can play in a variety of ways. Can stand in any position in the offensive line Can be a striker Or sometimes back down to play the role of a quarter-back and keep the ball pass well as well
Back in february The administrators watched Barca live in Spain at the away game at Real Betis.That game, Barca won 3-2, with Messi back down to play a passer and made three assists in a single game.
Messi is the genius player of the era. He can adapt to any plan. Play with players of any style. Which the size of Barca in the current season The other players were in that form. But Messi still supported the team that much. It is already considered good.
If Barca says he is the No. 1 team in the world, he should keep the No. 1 player with him, not let go of strengthening others.
Want to make the team better Get other players to play with Messi to level the squad together. Meaning there is no need to throw away Messi
And do not forget that Since Barca will get rid of a lot of senior players – Suarez, Vidal, Rakitic, Utiti or maybe another Pique, that means losing Messi again. Barca has almost no one left. Then will only rely on the young stars, will it be ok?
There is a saying that if Barca released Messi, Suarez and Rakitic this summer. In the whole club barca Only Ronald Kuman will ever score in a Champions League final. It’s pretty bad.
The next reason is equally important is that Messi is the symbol of Barcelona.
Messi grew up from La Masia to the top of the club. And helped the team win four European championships in the history of the Barca club since its establishment In an era where there was no Messi The team won one time in Europe, but when Messi had enough The team immediately won 4 more European championships.
Football fans expect Messi. Stay with the club for a long time Until the stud It is a great legend of the team. Ended the career beautifully
Is from the number of doors And the success that Messi made the team He deserves the highest honor from the club, isn’t he?
In the past in Barcelona There used to be a player who played one team and retired Carles Puyol, but when Bartomeu became the club president. Surprisingly, the legendary players Can not remain with the club throughout the years. In the end, they all have to move the team.
Big Tor Valdes moved to Manchester United in 2014, Xabi moved to Al Sadd in 2015, Pedro Rodriguez also moved to Chelsea in 2015. Iniesta moved to Vissel Kobe in 2018.
These players Fans wanted a beautiful ending like a one-club man, but it never happened. So there was an expectation with Messi. That will become a legend of the team until the last day of their career.
Messi deserves that kind of greatness. The last game in my career Walked off the field with standing ovations All the people Camp Nou Make a sign of praise to honor.

But if it ends up like this Means the last game of Messi The game was defeated by Bayern 8-2, a painful ending, no celebration. I didn’t say goodbye to my own fans. It was a really cruel separation.

[Latest situation]
That Barcelona The coach will do the duty of the tactics only. As for the contract Trading decisions And policies It is a matter of the club president. And all administrative boards
The problem we see is that the management gap and Messi are too far apart.
“Me and the club president, we didn’t talk. Since losing to Liverpool That was the last time we talked. “
When the gaps are so far apart No intimacy It makes the club side ready to do whatever. Without having to care much about Messi
Like Messi Who saw that the club could not move so strongly If still being the executive of this set Which since he could not do more Taking myself out Should be the best to end the problem
At this point, Spanish media analyzed that if Bartomez decided to leave. And speed up the process of electing a new president Messi may continue to change her mind. But if Bartomeu doesn’t go Messi is definitely not. Which is the reason Barca fans held up a banner to sack the president in front of the Camp Nou stadium last night.
Suppose Bartomeu doesn’t leave. What will be the next step? Messi will move on to move the team. By Messi, according to the contract that was signed That he has the right to tear the contract And move the team immediately That myself want
However, the contract document states that Messi’s free contract option It has been exhausted since June 21, 2020, and Messi has protested about going crazy or something this year, it is infected with COVID. The program has been postponed until August. Therefore the option must be postponed as well. How can Barca do this?
This seems like a big story, but it’s definitely over. Because if the players really intend to go How can Barca get hold of it? The club would not be willing to pay 1 million euros a week to people who have lost their hearts with the team.
Now the clubs Prepare to plan to accelerate negotiations on Messi Spanish media believe that only five teams have the potential to sign Messi.
The first team was Man City with Pep Guardiola, the man who used the best Messi as a coach. Besides that, Ferran Soriano is the CEO and Sorriano knows Messi well. Because in the past was the vice president of Barca club before Plus, don’t forget that City has another friend of Messi’s Gun Aguero.
The gambling bureau has legalized Manchester City as one of the favorites because of City’s money and style. Playing a short ball really suits Messi.
The second team is PSG, a team that dreams of winning a European title once. If you get Messi Go play with Neymar and Kiel.

Categories
News

Even only Alcohol’s Logo still Illegal in Thailand?

From the case of a complaint that A restaurant in Nonthaburi was arrested by the staff. Because the food menu was found with a logo of alcohol Illegal Section 32 of the 2008 Alcohol Control Act has caused widespread criticism on social media.
On August 23, 2020, Dr. Nipon Chinanontvej, Director of the Office of the Alcohol Control Committee (OIC), clarified that the office received a complaint through an information system to monitor violations of the tobacco product control law. And Alcoholic Beverages (TAS) on 21 Jan 2019 that the store has advertised alcohol
The competent official went to the inspection area on 24 January 2019, along with the police from the Pak Kret Police Station, found a large number of advertising media for alcoholic beverages, such as fire signs, freezers, food menus, and stickers on the walls around the shop. And beer cheer girls It’s not just a menu that has alcoholic beverages as the owner claims.
In addition, the officer recorded photos and videos on the day of the review. With an identification card showing Notify the objective and clarify the law to the shop owner according to the steps The shop owner interviewed that the competent official just said that it was an offense without explaining the law is not true in any way. In addition, the shop owner informed the competent official that Advertising media installed in the store Obtained from a representative of the alcoholic beverage manufacturer
Dr. Niphon continued that Restaurant operators should not accept advertising media for alcoholic beverages. Including various types of advertising media in the shop because if there is a complaint and the competent official has come down to check and find that there is such advertising media inside the store, it will be prosecuted according to the law.
The news team workpointTODAY Interviewed the restaurant owner who admitted that The wrong label is a white liquor label, two beer brands, a food menu sign with the beer logo on it. Which is during the inspection period from January to February 2019, there are no signs in the shop at present. And not a food menu that is news Which his son is a poster because he understands that But was wondering why he just had a summons Because it has been examined since 2019, I understand that the story is over Which economy like this comes with a lot of fines for their shop Increasing the burden and worry
While the staff informed the news team that The reason just had a fine because the lawsuit had to terminate the case before Inspection offices all over the country, not just in Bangkok or Nonthaburi

Categories
Misc.

Some Thai Foods I Do Recommends

Hello friends Today I have a food menu to suggest that we can eat together.

Talk about Thai food Including a wide variety of dishes For example, Tom Yum Kung, Namtok Laab Moo, Namtok Pork, Som Tam, Grilled Chicken, and Sticky Rice. Sometimes people like to eat it on skewers. Because it’s easy to eat and doesn’t need to clean up a lot. For example, grilled pork, fresh milk, grilled pork, grilled pork liver, fried chicken, skewers, grilled pork heart, grilled pork innards

For the menu that I will present today You can try ordering one from Grabfood Panda or Get it, and the delivery fee will vary depending on your friends’ location.

The menu that I want to present today is Roasted Omelette with Fermented Naem It’s a menu that doesn’t look like much.

Roasted Omelette with Fermented Naem
Roasted Omelette with Fermented Naem

But the taste is second to none. As for the price, it can reach a wide variety of customer groups. Because the price is more than 60 baht, not more than this

For the amount of rice and side dishes provided I have to admit that it is full enough for one person, in case you are a heavy eater, it may not feel full to your stomach. But for me, it was full. If more than this, you may become pregnant and feel discomfort later.

However, some of you may be concerned about the packaging. I personally think that the shop is packed well. And keep heat Makes food that has been received fresh and appetizing from rice that is hot right. And the side dish is not cold or dull either The cleanliness of the box ensures that You don’t have to worry about stomach pain after eating. Because the box that was brought to it was a good heat storage box And what I like best is The box can also be put in the microwave. This is suitable for people who live in condominiums and are inconvenient to heat food. Using the microwave to warm through the box directly. It will save time and do not need to clean anything complicated after eating.

Recommendations for friends who have not ordered through the service provider. There is one thing that needs to be paid attention to every time you order food, that is, the price of delivery. This will depend on the distance between the shop and your residence. And in some incidents of heavy rain or curfew events There may be no food ordering. Or add additional shipping fees in special cases Therefore would like you to order food Check the price of delivery carefully every time. If the shipping cost is quite high It is recommended to order more than 1 box of food, such as food for 50 baht, delivery cost 30, you should order 2-3 boxes to share the average delivery cost to 10 baht, it will look good and save time in ordering food.

Roasted Omelette with Fermented Naem 2
Roasted Omelette with Fermented Naem

Finally, some food If eaten in the event of too much or too often May contain sodium or fat That may cause various diseases Therefore, don’t forget to eat only and exercise every time. Because ordering food nowadays easier That means you have access to more delicious food sources. And if there is no good dietary control per day It may cause obesity, diabetes, and long-term pressure.

Categories
Misc.

Is it really good to save on DCA stocks?


Hello to all readers. We meet again on a somewhat pertinent investment topic.

Because after all this time I have plenty of time left each day. In addition to having read a book that appears to be polished to be able to organize ideas and use your time more efficiently, this provides an opportunity to sit back and listen and study various information about investing in the Thai stock exchange.

This topic will be written understanding my own experience. If any information is wrong, I apologize here.

What is DCA?
This question is probably the most heard in recent years. As more people pay attention to saving and investing

The meaning of DCA is that you can find it on Google because it has a wide variety of people.

For me, a DCA is a gradual purchase of the same amount of assets each month or week, or even as a gradual daily purchase.

Why did DCA leave?
Because investing is like life Therefore, investing for life is something that every ordinary human being should do.

If you have a billion Buying valuables seems like an easy task.

On the other hand, if you are a salaried man, you will be able to own certain assets. It may not be easy to spend all your money on just one thing.

So, it is the reason that Accumulation or DCA is the answer to your valuables as a billion investors.

How does DCA work?
DCA usually occurs in the stock market. You can open a share account at any bank in Thailand. Or open a share account at the same bank where you have a deposit account.

After opening an account, you can reload your account to start doing DCA right away.

In general, DCA is a function of the popular “Streaming” application.

When you have successfully reloaded the stock account, then DCA can be started using the general principle: you can define that.

What stocks will you buy gradually?
Little by little you will buy those shares. With what amount per month (The minimum purchase is 100 shares, so calculate enough money)
You want those shares to be bought. Every day of the month, for example, every 1/5/15/25 of each month.
After completing the setup, you have a duty, just wait for the time you have chosen. As you must remember, on each of those dates, funds will be debited from your stock account to DCA.

Don’t forget to also recharge enough for the DCA.

Is DCA really good?
real

Because DCA is better than being idle, not investing.
If a lot of DCA time is given (it is an investment that takes time)
If you are thinking of buying that asset for a lump sum, then DCA is better.
Is not true

If you want high returns for a short time (DCA is wrong)
If you have enough money to buy that asset You don’t need DCA (you’re already rich)
If you have a DCA with assets that continue to lose value (such as throwing money away)
Advantages and precautions of DCA
With a DCA, you can become the owner of a high-value asset by gradually building it up. (Low investment takes a long time to accumulate).
DCA will make assets less expensive. Because every time there is a purchase, the price of that asset can be cheap or expensive. Making that cost an average cost
The longer the DCA, the value of the asset only tends to increase. Increase wealth
But keep in mind that a good DCA is a good asset. (Therefore, there must be a detailed study of the assets that will be DCA each time)
It continues to drive DCA to assets that have a tendency to decline in value. Which resulted in a loss of the investment period also caused losses.
Presenting DCA from real experiences
And then it gets to the heart of the article. That led to the last paragraph of the article. I have been in the field to save DCA stocks myself for about 3-4 months so I would like to share my experience. As a guide for novice investors

As previously written, a typical DCA requires a date each month. For the system to buy accumulated for us Difficult conditions that can be defined as

The DCA is assigned every week (weekly).
Make DCA monthly (monthly) * Popular
DCA is required every 1/5/15/25 of every month.
Of course, a typical DCA will allow you to buy the stocks that interest you. At a price that is not too expensive But because sometimes Buy once a month and set a specific date. It may not be the best option for DCA.

The author has made the DCA in both normal and new formats. Both are separate accounts Making it possible to see the difference quite clearly